AAKG (L-Arginine-Alpha-Ketoglutarate) 1167mg
Alpha Ketoglutarate 818 mg
L-Arginine 348 mg
Non-Medicinal Ingredients: Cellulose, Stearic Acid (vegetable source) Silica and Vegetarian Coating
When consumed in balance with cysteine, glycine, lysine and other nutrients Arginine AKG is a powerful supplement for those with demanding lifestyles, as it assists in the replenishment of glutathione, the removal of toxic ammonia through the urea cycle, the regulation of blood pressure, stimulation of hormones, growth of bone and muscle, regeneration of tissues, and many other critical functions.
Arginine alpha-ketoglutarate (AAKG) contains two molecules of arginine bound to one of alpha-ketoglutarate (AKG), an intermediate compound in the Krebs cycle that determines the overall rate of energy production in cells and the organism. AKG is also the source of the amino acids glutamate and glutamine. Glutamate is an ingredient to glutathione synthesis along with cysteine and glycine. Paragon’s clinical metabolic testing has shown that glutamate can be depleted by toxins, stress, and other oxidative stressors. AKG then becomes a useful nutrient in helping reestablishing the supply of glutamate. Glutamate is also the main excitatory neurotransmitter in the brain and can increase bone formation. Glutamine is the main source of energy for cell division and enhances protein, muscle development, and immune function.
As a key molecule in the Krebs cycle, alpha-ketoglutarate is also a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein degradation in muscles. AKG as a precursor of glutamate and glutamine is a central metabolic fuel for cells of the gastrointestinal tract as well. AKG can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in the skeletal muscles and can be used in clinical applications. In addition to these health benefits, a recent study has shown that AKG can extend the lifespan of adult Caenorhabditis elegans worm by inhibiting ATP synthase and TOR. AKG not only extends lifespan, but also delays age-related disease.
Arginine, apart from being a component of proteins, stimulates the release of hormones such as insulin, glucagon, prolactin, and growth hormone. This results in the production of insulin-like growth factor 1 (IGF-1). IGF-1 enhances protein synthesis and thus increases muscle development. Arginine is also broken down into ornithine and creatine. Ornithine is essential for cell growth and division, while creatine is important for muscle contraction.
Arginine also plays a critical role in the nitric oxide and urea cycles.
L-arginine is broken down into nitric oxide (NO) in various tissues. Depending on where it’s produced, nitric oxide plays a critical role in regulating diverse functions in the body:
In the brain, it is a messenger molecule between nerves
In the immune system, it mediates the activity of white blood cells
In the cardiovascular system, it has protective effects by relaxing blood vessels. This increases blood supply and oxygen delivery around the body, and aids in the removal of waste.
L-arginine is also involved in the removal of toxins by forming urea, which is filtered out of the body through urine.
In the liver, L-arginine is converted to glucose and alpha-ketoglutarate. Therefore, it acts as a potential source of energy, and as a potential source of glutamate for glutathione synthesis.
Arginine is obtained from food and synthesized in the body. It is therefore referred to as a semi-essential amino acid. In healthy adults, food and synthesis in the body are sufficient to meet the necessary demands for this amino acid. These demands include tissue repair, synthesis of proteins, and maintenance of immune function. Therefore, during periods of rapid growth, physical stress, or injury, the supply of L-arginine may be insufficient to meet the body’s needs. During this time, L-arginine taken as a dietary supplement can help maintain muscle mass and improve bodily function.
Supplementing L-arginine can improve the capacity for exercise. This improvement can be seen immediately after consuming arginine. Additionally, long-term improvements are seen due to increased protein synthesis in muscles.
In addition to its performance-enhancing effects, arginine has proven to be a safe and effective therapy for high blood pressure, type 2 diabetes, and erectile dysfunction.
Arginine reduces infection rates in conditions where the body is prone to infection, such as surgery or critical illness.
AAKG combines the potential benefits of both molecules, L-arginine and alpha-ketoglutarate. For those with heavy metals toxicities or excess stress loads, it can be combined with glycine and cysteine and assist in liver.
Paragon’s clinical metabolic testing shows that when used in balance with cysteine and glycine, arginine AKG and other nutrients have the ability to synthesize glutathione to help maintain healthy liver tissue & function, cellular detoxification, healthy lung tissue and function, and enhance cellular health and longevity. These qualities can make AAKG beneficial for active people, the elderly, those with a past history of heavy metals, liver problems, pneumonia and lung problems, alcohol problems, heavy consumption of Tylenol or other acetaminophen products, and those exposed to polluted environments.
Our pioneering metabolic research has helped produce the most natural, bio-available combinations of nutrient required to address imbalances and biochemical toxicities determined through metabolic testing.BACK TO PRODUCTS
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